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1993 1
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1996 4
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1999 5
2000 4
2001 8
2002 4
2003 2
2004 7
2005 5
2006 3
2007 9
2008 6
2009 3
2010 12
2011 12
2012 14
2013 13
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2015 16
2016 14
2017 19
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256 results

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Page 1
COVID-19 and Brain Aging: What are the Implications of Immunosenescence?
Keller GS, Medeiros EB, Dos Santos MLC, Lidio AV, Kucharska E, Budni J. Keller GS, et al. Curr Aging Sci. 2023;16(2):89-96. doi: 10.2174/1874609816666221228103320. Curr Aging Sci. 2023. PMID: 36579393
There is a decrease in B and T lymphocytes and CD4+ lymphocytes lose the CD28 protein expression that is needed for costimulation, leading to reduced response to viral infections. ...There are several pathways that could explain the susceptibility to the COVID-19 infection …
There is a decrease in B and T lymphocytes and CD4+ lymphocytes lose the CD28 protein expression that is needed for costimulation, le …
CD28 Deficiency Ameliorates Thoracic Blast Exposure-Induced Oxidative Stress and Apoptosis in the Brain through the PI3K/Nrf2/Keap1 Signaling Pathway.
Cong P, Tong C, Liu Y, Shi L, Shi X, Zhao Y, Xiao K, Jin H, Liu Y, Hou M. Cong P, et al. Oxid Med Cell Longev. 2019 Dec 4;2019:8460290. doi: 10.1155/2019/8460290. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31885821 Free PMC article.
However, it has not been investigated. To explore the effects of CD28 on thoracic blast exposure-induced brain injury and its potential molecular mechanisms, a mouse model of thoracic blast exposure-induced brain injury was established. ...Additionally, CD …
However, it has not been investigated. To explore the effects of CD28 on thoracic blast exposure-induced brain injury and its …
CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity.
Haydar D, Ibañez-Vega J, Crawford JC, Chou CH, Guy CS, Meehl M, Yi Z, Perry S, Laxton J, Cunningham T, Langfitt D, Vogel P, DeRenzo C, Gottschalk S, Roussel MF, Thomas PG, Krenciute G. Haydar D, et al. Cancer Res Commun. 2023 Dec 1;3(12):2430-2446. doi: 10.1158/2767-9764.CRC-23-0424. Cancer Res Commun. 2023. PMID: 37971169 Free PMC article.
Understanding the intricate dynamics between adoptively transferred immune cells and the brain tumor immune microenvironment (TIME) is crucial for the development of effective T cell-based immunotherapies. ...To enhance therapeutic effectiveness and persistence, we incorpo …
Understanding the intricate dynamics between adoptively transferred immune cells and the brain tumor immune microenvironment (TIME) i …
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.
Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. Park H, et al. Nat Immunol. 2005 Nov;6(11):1133-41. doi: 10.1038/ni1261. Epub 2005 Oct 2. Nat Immunol. 2005. PMID: 16200068 Free PMC article.
Here we have evaluated in vitro and in vivo the requirements for the differentiation of naive CD4 T cells into effector T helper cells that produce IL-17. This process required the costimulatory molecules CD28 and ICOS but was independent of the cytokines and transcription …
Here we have evaluated in vitro and in vivo the requirements for the differentiation of naive CD4 T cells into effector T helper cells that …
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape.
Hegde M, Mukherjee M, Grada Z, Pignata A, Landi D, Navai SA, Wakefield A, Fousek K, Bielamowicz K, Chow KK, Brawley VS, Byrd TT, Krebs S, Gottschalk S, Wels WS, Baker ML, Dotti G, Mamonkin M, Brenner MK, Orange JS, Ahmed N. Hegde M, et al. J Clin Invest. 2016 Aug 1;126(8):3036-52. doi: 10.1172/JCI83416. Epub 2016 Jul 18. J Clin Invest. 2016. PMID: 27427982 Free PMC article.
In preclinical models of glioblastoma, antigen escape variants can lead to tumor recurrence after treatment with CAR T cells that are redirected to single tumor antigens. Given the heterogeneous expression of antigens on glioblastomas, we hypothesized that a bispeci …
In preclinical models of glioblastoma, antigen escape variants can lead to tumor recurrence after treatment with CAR T cells that are redire …
Immunosuppression in patients who die of sepsis and multiple organ failure.
Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD 2nd, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS. Boomer JS, et al. JAMA. 2011 Dec 21;306(23):2594-605. doi: 10.1001/jama.2011.1829. JAMA. 2011. PMID: 22187279 Free PMC article.
Control spleens (n = 29) were obtained from patients who were declared brain-dead or had emergent splenectomy due to trauma; control lungs (n = 20) were obtained from transplant donors or from lung cancer resections. ...The median duration of sepsis was 4 days (range, 1-40 …
Control spleens (n = 29) were obtained from patients who were declared brain-dead or had emergent splenectomy due to trauma; control …
Prospective Evaluation of CD45RA+/CCR7- Effector Memory T (T(EMRA)) Cell Subsets in Patients with Primary and Secondary Brain Tumors during Radiotherapy of the Brain within the Scope of the Prospective Glio-CMV-01 Clinical Trial.
Scheer I, Becker I, Schmitter C, Semrau S, Fietkau R, Gaipl US, Frey B, Donaubauer AJ. Scheer I, et al. Cells. 2023 Feb 4;12(4):516. doi: 10.3390/cells12040516. Cells. 2023. PMID: 36831183 Free PMC article.
Radiotherapy (RT) of the brain is a common treatment for patients with high-grade gliomas and brain metastases. ...Further, the distribution of the subsets of T(EMRA) cells based on the expression of CD27, CD28, and CD57 is highly dependent on the CMV serosta …
Radiotherapy (RT) of the brain is a common treatment for patients with high-grade gliomas and brain metastases. ...Further, th …
Conservation of structural and interactional features of CD28 and CD80/86 molecules from Nile tilapia (Oreochromis niloticus).
Huang Y, Wang Z, Zheng Q, Tang J, Cai J, Lu Y, Jian J. Huang Y, et al. Fish Shellfish Immunol. 2018 Jan;72:95-103. doi: 10.1016/j.fsi.2017.10.008. Epub 2017 Oct 24. Fish Shellfish Immunol. 2018. PMID: 29074133
Yeast two-hybrid assay showed that On-CD28 directly interacted with On-CD80/86. On-CD28 and On-CD80/86 transcripts were detected in all the examined tissues of healthy Nile tilapia, and the highest expression levels of On-CD28 and On-CD80/86 were detected in …
Yeast two-hybrid assay showed that On-CD28 directly interacted with On-CD80/86. On-CD28 and On-CD80/86 transcripts were detect …
Blocking B7-1/CD28 Pathway Diminished Long-Range Brain Damage by Regulating the Immune and Inflammatory Responses in a Mouse Model of Intracerebral Hemorrhage.
Ma L, Shen X, Gao Y, Wu Q, Ji M, Luo C, Zhang M, Wang T, Chen X, Tao L. Ma L, et al. Neurochem Res. 2016 Jul;41(7):1673-83. doi: 10.1007/s11064-016-1883-3. Epub 2016 Mar 15. Neurochem Res. 2016. PMID: 26980009
Acute brain injuries can activate bidirectional crosstalk between the injured brain and the immune system. ...The treatment with anti-B7-1 antibody significantly lowered immune function, and reduced the latency of water maze on 18 and 20 days, the ratio of IFN-gamma …
Acute brain injuries can activate bidirectional crosstalk between the injured brain and the immune system. ...The treatment wi …
HER2-Specific Chimeric Antigen Receptor-Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial.
Ahmed N, Brawley V, Hegde M, Bielamowicz K, Kalra M, Landi D, Robertson C, Gray TL, Diouf O, Wakefield A, Ghazi A, Gerken C, Yi Z, Ashoori A, Wu MF, Liu H, Rooney C, Dotti G, Gee A, Su J, Kew Y, Baskin D, Zhang YJ, New P, Grilley B, Stojakovic M, Hicks J, Powell SZ, Brenner MK, Heslop HE, Grossman R, Wels WS, Gottschalk S. Ahmed N, et al. JAMA Oncol. 2017 Aug 1;3(8):1094-1101. doi: 10.1001/jamaoncol.2017.0184. JAMA Oncol. 2017. PMID: 28426845 Free PMC article. Clinical Trial.
INTERVENTIONS: Monotherapy with autologous VSTs specific for cytomegalovirus, Epstein-Barr virus, or adenovirus and genetically modified to express HER2-CARs with a CD28.zeta-signaling endodomain (HER2-CAR VSTs). MAIN OUTCOMES AND MEASURES: Primary end points were feasibil …
INTERVENTIONS: Monotherapy with autologous VSTs specific for cytomegalovirus, Epstein-Barr virus, or adenovirus and genetically modified to …
256 results